SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF OXIME ESTERS FROM DIHYDROCUMIC ACID

Yanqing Gao, Jie Song, Shibin Shang, Dan Wang, Jian Li

Abstract


Dihydrocumic acid was prepared from β-pinene through oxidation and dehydration. Then, ten oxime esters from dihydrocumic acid were synthesized. Reaction conditions of the oxime esters were adjusted and their structures were characterized by IR, 1H-NMR, MS, and elemental analysis. The antibacterial activity of these newly synthesized oxime esters against Gram-negative bacteria and Gram-positive bacteria was also investigated using the inhibition zone method. The preliminary results indicated that seven compounds displayed better antibacterial activity against Gram-negative bacteria compared with bromogeramine, a commercially available antibacterial agent.

Keywords


β-pinene; Dihydrocumic acid; Oxime esters; Antibacterial activity

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