Electrospun Carboxymethyl Chitosan Nanofibers for Antibacterial Activity for Wound Healing

Hassan Mohamed Ibrahim, Amira Dakrory, Anke Klingner, Ahmed El-Masry

Abstract


Electrospinning of carboxymethyl chitosan (CMCS) solutions in water was studied by adding poly (vinyl alcohol) (PVA) as “guest” polymer. The properties of the CMCS/PVA solutions measured, and effects of the polymer concentration, CMCS/PVA mass ratio and processing parameters on the electrospinnability of CMCS/PVA were investigated. Morphology of the electrospun CMCS/PVA observed by using scanning electron micrographs. Results showed that the ultra-fine fibers could be generated after addition of PVA in different mass ratios of CMCS to PVA from 4–8 wt. % CMCS/PVA solutions. Antibacterial activity of electrospun fibers prepared against Gram (-ve) and Gram (+ve) bacteria is measured via Disk Diffusion Method. Electrospun CMCS/PVA nanofiberwebs show good antibacterial effects towards Gram (+ve) and Gram (-ve) bacteria. Antibacterial activities of electrospun nanofiberwebs increased by increasing the CMCS percent in the electrospun membrane. Results of the higher antibacterial activity of electrospun CMCS/PVA nanofiberwebs oriented its potential applications in wound dressings.

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