Anti-photoaging Effects of Steam-exploded Pine (Pinus densiflora) Extract in Ultraviolet B Irradiation-damaged HaCaT Keratinocytes

Authors

  • Ji Young Jung Department of Environmental Materials Science, Gyeongsang National University, Jinju 52828 Republic of Korea; Institute of Agriculture and Life Sciences, Gyeongsang National University, Jinju 52828 Republic of Korea
  • Si Young Ha Yang Department of Environmental Materials Science, Gyeongsang National University, Jinju 52828 Republic of Korea; Institute of Agriculture and Life Sciences, Gyeongsang National University, Jinju 52828 Republic of Korea
  • Jae-Kyung Yang Department of Environmental Materials Science, Gyeongsang National University, Jinju 52828 Republic of Korea; Institute of Agriculture and Life Sciences, Gyeongsang National University, Jinju 52828 Republic of Korea

Keywords:

Pinus densiflora, Steam-explosion, UVB, HaCaT keratinocytes, Anti-photoaging

Abstract

Ultraviolet B (UVB) irradiation causes photoaging, such as wrinkles, roughness and dryness of the skin, and it activates the production of reactive oxygen species (ROS) and inflammatory cytokines. In this study, the anti-photoaging activity of SEP-E (steam-exploded pine extract) was evaluated in HaCaT keratinocytes damaged by UVB irradiation. SEP-E treatment showed cytoprotective effects in HaCaT keratinocytes irradiated with UVB (40 mJ/cm2). SEP-E treatment reduced ROS overproduction and promoted the expression of antioxidant enzymes, such as catalase, superoxide dismutase 1, and superoxide dismutase 2. Additionally, SEP-E treatment suppressed the expression of inflammatory cytokines, including interleukin 6, interleukin 8, and monocyte chemoattractant protein-1. Consequently, SEP-E shows potential as a natural material for photoaging treatment.

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Published

2024-05-17

Issue

Vol. 19 No. 3 (2024)

Section

Research Article or Brief Communication